Blood is the lifeline of the human body, a vital fluid that carries oxygen, nutrients, hormones, and waste products to and from cells, regulating temperature, defending against infection, and maintaining the delicate balance of internal systems.
At the heart of these functions are red blood cells, which contain hemoglobin—a protein responsible for transporting oxygen to tissues and organs. Anemia, one of the most common blood disorders, occurs when the body lacks enough healthy red blood cells or hemoglobin to meet its needs. Fatigue, dizziness, cold hands and feet, and shortness of breath are common symptoms. Other symptoms, such as yellowish skin, brain fog, irregular heartbeats or palpitations, chest pain, headaches, and poor appetite, vary in severity depending on the underlying cause and the degree of anemia.
The World Health Organization estimates that a quarter of the world’s population suffers from some type of anemia, with most cases in women and pre-school aged children.
Anemias from Nutrient Deficiencies
Anemia can result from several factors including nutrient deficiencies, inadequate absorption of nutrients, inflammation, infection, chronic disease, and genetic blood cell disorders. For the purpose of this article, we will focus on anemias caused by nutritional deficiencies.
Iron-deficiency anemia. This type of anemia is most prevalent, with 30% of the global population affected. It occurs when the body does not have enough iron to produce sufficient hemoglobin, the protein in red blood cells that carries oxygen. This can be a result of not enough iron getting in (deficient diet, poor absorption (e.g., as a result of conditions like celiac disease or gastric surgery), or increased need (e.g., pregnancy or growth spurts), or too much iron being lost (e.g., heavy menstruation or gastrointestinal bleeding). Without sufficient iron, the body’s ability to generate healthy red blood cells is impaired, leading to diminished oxygen delivery to tissues and organs.
Megaloblastic anemia: This type of anemia results from a lack of vitamin B12 or vitamin B9 (folate). Both B12 and folate facilitate DNA synthesis in the developing blood cells, allowing them to mature and divide. Without adequate B12 and folate, blood cells become large and structurally abnormal while their inner contents are not fully developed. Causes of megaloblastic anemia include insufficient dietary intake (common in vegans and vegetarians); increased need as in pregnancy; and malabsorption due to gastrointestinal disorders, pernicious anemia (lack of intrinsic factor in the stomach that facilitates absorption of B12), or taking certain medications that interfere with absorption. Excessive alcohol consumption can interfere with the bone marrow’s ability to produce healthy red blood cells and deplete essential nutrients like folate.
How Anemia Is Diagnosed
Diagnosing anemia involves evaluation of presenting symptoms, a physical exam, and laboratory tests. A complete blood count (CBC) measures the key components of blood, including red blood cell count, hemoglobin levels, and hematocrit (the percentage of blood made up of red blood cells). Low values are strong indicators of anemia.
Additional tests may be needed to pinpoint the cause. For example, checking iron, vitamin B12, and folate levels can identify nutritional deficiencies, while a peripheral blood smear examines the size and shape of red blood cells to detect genetic abnormalities like sickle cell anemia or thalassemia. In some cases, further testing may be required. Consulting a healthcare provider at the first sign of symptoms ensures accurate diagnosis and effective treatment.
It is wise to get anemia corrected in a timely manner to avoid complications such as a weakened immune system, possible heart or lung complications and birth complications in pregnant women.
Preventing Anemia Through Diet Modification
Increasing intake of iron-rich foods like lean meats, beans, and leafy greens and/or taking iron, vitamin B12, folate, and reduced and buffered vitamin C supplements can correct deficiencies and ensure adequate intake and optimal absorption of the key nutrients needed for healthy red blood cell production:
Iron-Rich Foods. Lean meats, poultry, liver, and fish such as salmon and sardines, contain a form of iron known as “heme” iron, which is easily absorbed into the body. Plant-based sources of iron such as spinach, kale, lentils, beans, tofu, and quinoa contain less absorbable “non-heme” iron. Pair these with vitamin C-rich foods (e.g., citrus fruits, bell peppers, or strawberries) to enhance absorption.
Vitamin B12 Sources. B12 is found naturally in animal products like eggs, dairy, and fish. For those on a plant-based diet, fortified foods or high-quality supplements are essential to meet daily needs.
Folate-Rich Foods. Leafy greens such as spinach and romaine lettuce, citrus fruits like oranges, and legumes such as chickpeas and black-eyed peas are excellent sources.
Additional Nutrients: Copper and zinc support hemoglobin production and are found in nuts, seeds, and shellfish. Beta carotene (Vitamin A) found in sweet potatoes, carrots, and cantaloupe, helps mobilize iron for hemoglobin synthesis. Buffered vitamin C is essential for iron metabolism. Follow an alkalinizing diet using these 7 principles.
Supplementing with PERQUE® Products
For those unable to meet their iron needs through diet alone, supplements can be beneficial. Vitamin B12 and folate supplements are often recommended to support healthy red blood cell production. However, not all supplements are equally effective. PERQUE® offers pharmaceutical-grade, clinically validated products formulated for superior bioavailability and effectiveness. (For example, PERQUE uses the superior, hydroxocobalamin form of B12. Hydroxocobalamin lasts longer and raises B12 blood concentrations higher than other forms. Hydroxocobalamin requires no intrinsic factor and is taken up directly by mucous membranes regardless of digestive competence.* Hydroxocobalamin is easily converted to active but short-lived methylcobalamin and adenosyl-cobalamin as needed in the body.)
PERQUE Hematin Anemia Guard™ is a highly effective supplement designed to address the nutritional deficiencies underlying most types of anemia. Its 100% bioavailability ensures maximum absorption and utilization by the body. Unlike conventional iron supplements, which may cause gastrointestinal discomfort or have low absorption rates, PERQUE Hematin Anemia Guard uses ionized ferrous aspartate, a gentle and readily absorbed form of iron.
The formula is enriched with essential vitamins and minerals that support red blood cell production and overall blood health:
- Vitamin B6 supports hemoglobin production.
- Vitamin B12 (hydroxocobalamin) aids in DNA synthesis and red blood cell formation.
- Vitamin C enhances iron absorption and combats oxidative stress.
- Folate helps develop healthy red blood cells. (Note that folic acid is never recommended. While methylfolate is used by many, PERQUE prefers to use the safer folinic acid that is not synthetic folic acid but also is well absorbed by people who don’t tolerate methyl form.)
- Niacin and magnesium improve oxygen delivery and energy metabolism.
- Copper facilitates effective iron transport in the bloodstream.
This synergistic combination targets anemia’s root causes by replenishing depleted nutrients, improving red blood cell function, and enhancing oxygen transport throughout the body. The result is increased energy, reduced fatigue, and overall improved quality of life.
For sustained improvement, PERQUE Hematin Anemia Guard works best when integrated into a comprehensive approach that includes a nutrient-dense diet. Foods rich in iron, folate, and other essential nutrients—such as leafy greens, legumes, lean proteins, and fortified products—can help maintain healthy blood levels. For individuals with dietary restrictions, such as vegetarians, vegans, or those with absorption issues, this supplement is especially valuable for bridging nutritional gaps.
PERQUE Life Guard™ and PERQUE Life Guard™ mini multivitamin: Provides a full spectrum of essential vitamins and minerals, including iron, B12, folate, and zinc, to address and prevent deficiencies while supporting overall health.
PERQUE Activated B12 Guard™: Delivers hydroxocobalamin, the superior form of vitamin B12, for optimal absorption, particularly for individuals with malabsorption issues or increased needs.
By incorporating these targeted dietary strategies and supplements, individuals can proactively support red blood cell health, prevent anemia, and optimize their energy levels and well-being. Together, targeted supplementation and dietary support can significantly reduce anemia symptoms, restore energy, and promote long-term health and vitality.
Living Well with Anemia
Managing anemia effectively requires a combination of medical treatment, dietary adjustments, and lifestyle changes. Working closely with a healthcare provider to identify and address the root cause is the first step.
Dietary Habits for Long-Term Health: Maintaining a balanced diet rich in iron, vitamin B12, folate, and other essential nutrients is key to supporting healthy red blood cell production. Incorporating foods like lean meats, legumes, and leafy greens into daily meals can help maintain optimal levels. Supplements, such as PERQUE’s high-quality products, can fill any gaps to ensure consistent nutrient intake.
Monitoring and Self-Care: Routine blood tests to track hemoglobin and iron levels are essential for individuals managing anemia. Staying active with light exercise, when possible, improves circulation and energy levels, while adequate rest helps combat fatigue.
Stress Management and Overall Well-Being: Chronic stress can worsen symptoms of anemia. Mindfulness practices like meditation or yoga can support emotional well-being and reduce the physical toll of stress. Engaging in enjoyable activities and seeking social support are equally important for maintaining a positive outlook.
With the right combination of treatment, nutrition, and lifestyle strategies, individuals with anemia can lead active, fulfilling lives while minimizing the risk of recurrence or complications.
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*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
